Correction: Phenotypic heterogeneity promotes adaptive evolution

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Correction: Phenotypic heterogeneity promotes adaptive evolution

[This corrects the article DOI: 10.1371/journal.pbio.2000644.].

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Phenotypic heterogeneity promotes adaptive evolution

Genetically identical cells frequently display substantial heterogeneity in gene expression, cellular morphology and physiology. It has been suggested that by rapidly generating a subpopulation with novel phenotypic traits, phenotypic heterogeneity (or plasticity) accelerates the rate of adaptive evolution in populations facing extreme environmental challenges. This issue is important as cell-t...

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Phenotypic heterogeneity in modeling cancer evolution

The unwelcome evolution of malignancy during cancer progression emerges through a selection process in a complex heterogeneous population structure. In the present work, we investigate evolutionary dynamics in a phenotypically heterogeneous population of stem cells (SCs) and their associated progenitors. The fate of a malignant mutation is determined not only by overall stem cell and non-stem c...

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Phenotypic Heterogeneity and the Evolution of Bacterial Life Cycles

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ژورنال

عنوان ژورنال: PLOS Biology

سال: 2017

ISSN: 1545-7885

DOI: 10.1371/journal.pbio.1002607